Human Neural Stem Cell Tropism - 857 Words

ARTICLE TITLE: Human Neural Stem Cell Tropism to Metastatic Breast Cancer ESSAY TITLE: The Investigation of a therapeutic implication on metastatic breast cancer with a specialized human neural stem cell that is programed to secrete carboxylesterase combined with activated form of an ionotecan by targeting a specific tumor site and major cytokine involved in mediating susceptibility of neural stem cells to breast cancer cells. SCIENTIFIC SUMMARY: Metastatic Breast Cancer is characterized as a severe stage of the breast cancer that continuously spread to other organs. In order to propose a chemotherapy mechanism to the metastatic breast cancer, Aboody and her group induced human neural stem cell (NSC) in a preclinical nude mouse model to target tumor metastases. They were able to propose a therapeutic implication that may prevent the progression of the metastatic by confirming a significant correlation relationship between NSC tumor with hallmarks of breast cancer, by finding a major cytokine (IL-6) that attracts NSC tropism to breast cancer cells, by determining the specific tumor metastatic sites of NSCs with IL-6 expression, and by designing a NSCs that can secrete an enzyme involved in drug metabolism. (Figure 1,2,5) Both negative and positive result experiment verified that NSCs were selectively migrating and invading tumor and metastases on selected sites of tumor metastases, which are lymph node, lung, femur, and liver in the early stage and brain at a later stage.Show MoreRelatedMicroglial and Neurological Disorder2037 Words   |  9 Pageswell as neural development disorders. Emerging evidence implicates microglial play critical roles to the CNS development of the brain. Microglial are unique population arise from immature yolk-sac macrophages that migrate and colonize the developing brain (Ginhoux et al., 2010; Ransohoff and Cardona, 2010). Interestingly, microglial (or their precursor cells) are selectively integrating into proliferative neurogenic zone of the proliferation and regulating the size of neural precursor cell pool viaRead MoreThe And Of The Structure Of Dna3909 Words   |  16 Pagesaltering the neurons with lower resolution methods such as electrodes or drugs. This method has some fundamental flaws as electrodes cannot distinguish between different cell types (Crick 1979.) In addition the drug method were very slow, sometimes taking days or months. In the following years scientists were able to target specific cells such as temperature and chemicals (alexander et all 2009), however the precision of light is unmatched. In addition light g ives millisecond precision which is very importantRead MoreNeoplasia10526 Words   |  43 Pagesprocess of new growth whilst Neoplasm means a new growth. Sometimes, the parenchyma cells stimulate the formation of an abundant collagenous stroma, referred to as desmoplasia. Some tumours e.g. some cancers of breast are stony hard or scirrhous. Sarcomas have little connective tissue stroma and so are fleshy. Pseudo tumours: i) An ectopic rest of normal tissue is sometimes called a choristoma e.g a rest of adrenal cells under the kidney capsule or a pancreatic nodular rest in the mucosa of the small